Gert Kiss

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

Justin B. Siegel, Alexandre Zanghellini, Helena M. Lovick et al. · Science · 2010 · 927 citations

Engineering, Biochemistry, Chemistry +17

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Robert J. Nichols, Franziska Haderk, Carlos Stahlhut et al. · Nature Cell Biology · 2018 · 418 citations

Medicine, Molecular Biology, Oncology +16

Iterative approach to computational enzyme design

Heidi K. Privett, Gert Kiss, Toni M. Lee et al. · Proceedings of the National Academy of Sciences · 2012 · 338 citations · Full text

Life Sciences, Biochemistry, Computational Chemistry +16

Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59

Olga Khersonsky, Gert Kiss, Daniela Röthlisberger et al. · Proceedings of the National Academy of Sciences · 2012 · 240 citations · Full text

Life Sciences, Biotechnology, Chemistry +17

Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution

Olga Khersonsky, Daniela Röthlisberger, Andrew M. Wollacott et al. · Journal of Molecular Biology · 2011 · 182 citations · Full text

Engineering, Biotechnology, Computational Design +14