J.P. Bacik

Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning

Justin R. Klesmith, J.P. Bacik, Emily E. Wrenbeck et al. · Proceedings of the National Academy of Sciences · 2017 · 168 citations · Full text

Life Sciences, Biochemistry, Evolutionary Biology +16

Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition

Katherine M. Davis, Kelsey R. Schramma, William A. Hansen et al. · Proceedings of the National Academy of Sciences · 2017 · 106 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease

Terrence W. James, Natalia Frias‐Staheli, J.P. Bacik et al. · Proceedings of the National Academy of Sciences · 2011 · 100 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Origin of High Stereocontrol in Olefin Cyclopropanation Catalyzed by an Engineered Carbene Transferase

Antonio Tinoco, J.P. Bacik, Daniela Maria Carminati et al. · ACS Catalysis · 2018 · 87 citations · Full text

Pharmacy, Biochemistry, Chemistry +17

Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion

J.P. Bacik, Garrett E. Whitworth, Keith A. Stubbs et al. · Chemistry & Biology · 2012 · 82 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14