Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, Richard D. Caldwell, +17

Bioorganic & Medicinal Chemistry Letters

Naphthoic Acid-based AnalogsBiochemistryG Protein-coupled ReceptorMedicineNatural Sciences +10

Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor

Derek M. Shore, Gemma L. Baillie, Dow P. Hurst, +6

Journal of Biological Chemistry

Cannabis UseOrg27569-binding Site OverlapsBiochemistryFunctional SelectivityMedicine +11

Cyclic Benzamides as Mixed Dopamine D2/Serotonin 5-HT2 Receptor Antagonists: Potential Atypical Antipsychotic Agents

Mark H. Norman, Greg C. Rigdon, Frank Navas, +1

Journal of Medicinal Chemistry

FXR agonist activity of conformationally constrained analogs of GW 4064

Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, Richard D. Caldwell, +14

Bioorganic & Medicinal Chemistry Letters

G Protein-coupled ReceptorFunctional SelectivityMolecular BiologyConformational StudyFxr Agonist Activity +2

Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene

Jonathan Y. Bass, Justin A. Caravella, Lihong Chen, +14

Bioorganic & Medicinal Chemistry Letters

Drug TargetFunctional SelectivityMedicineHeteroaryl ReplacementsFarnesoid X Receptor +6

Synthesis and Evaluation of Heterocyclic Carboxamides as Potential Antipsychotic Agents

Mark H. Norman, Frank Navas, James B. Thompson, +1

Journal of Medicinal Chemistry

Psychotropic MedicationHeterocyclic AnaloguesPsychopharmacologyOrganic ChemistryPharmacotherapy +15

Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene

Adwoa Akwabi-Ameyaw, Justin A. Caravella, Lihong Chen, +11

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyFunctional SelectivityMedicineMechanism Of ActionMolecular Biology +7

Structure−Activity Relationships of a Series of Substituted Benzamides:  Potent D₂/5-HT₂ Antagonists and 5-HT_1a Agonists as Neuroleptic Agents

Mark H. Norman, Greg C. Rigdon, William R. Hall, +1

Journal of Medicinal Chemistry

Substituted BenzamidesPsychopharmacologyPharmacotherapyPharmaceutical ChemistrySocial Sciences +19

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

Jing Fang, Adwoa Akwabi-Ameyaw, Jonathan Britton, +8

Bioorganic & Medicinal Chemistry Letters

3-Alkyl NaphthalenesHormonal ReceptorOrganic ChemistryPharmacologySynthetic Chemistry

2-(Anilinomethyl)imidazolines as α₁ Adrenergic Receptor Agonists:  the Discovery of α₁_a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues

Stephen J. Hodson, Michael J. Bishop, Jason D. Speake, +8

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistrySulfide AnaloguesBiochemistrySulfone Oxidation State +11