Richard D. Caldwell

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Han Dai, April Case, Thomas V. Riera et al. · Nature Communications · 2015 · 197 citations · Full text

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, Richard D. Caldwell et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 137 citations · Full text

Naphthoic Acid-based Analogs, Biochemistry, G Protein-coupled Receptor +12

Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases

Richard D. Caldwell, Hui Qiu, Ben Askew et al. · Journal of Medicinal Chemistry · 2019 · 136 citations · Full text

Novel Therapy, Medicine, Tyrosine Kinase +14

FXR agonist activity of conformationally constrained analogs of GW 4064

Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, Richard D. Caldwell et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 61 citations · Full text

G Protein-coupled Receptor, Functional Selectivity, Molecular Biology +4

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

Jonathan Y. Bass, Richard D. Caldwell, Justin A. Caravella et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 55 citations · Full text

Molecular Pharmacology, Biochemistry, Functional Selectivity +9