Chris Leiske

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

Robert P. Lyon, Jocelyn R. Setter, Tim D. Bovee et al. · Nature Biotechnology · 2014 · 445 citations

Pharmacy, Pharmaceutics, Pharmacology +16

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon et al. · Bioconjugate Chemistry · 2013 · 246 citations

Pharmacy, Oncology, Pharmacology +17

The Methylene Alkoxy Carbamate Self‐Immolative Unit: Utilization for the Targeted Delivery of Alcohol‐Containing Payloads with Antibody–Drug Conjugates

Robert V. Kolakowski, Karl T. Haelsig, Kim K. Emmerton et al. · Angewandte Chemie International Edition · 2016 · 77 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +17

Measurement of <i>in Vivo</i> Drug Load Distribution of Cysteine-Linked Antibody–Drug Conjugates Using Microscale Liquid Chromatography Mass Spectrometry

Shawna Hengel, Russell J. Sanderson, John Valliere‐Douglass et al. · Analytical Chemistry · 2014 · 71 citations

Pharmacy, Biochemistry, Pharmaceutics +17

Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability

Django Sussman, Lori Westendorf, David W. Meyer et al. · Protein Engineering Design and Selection · 2018 · 56 citations

Pharmacy, Medicinal Chemistry, Pharmaceutics +17