Enhanced Activity of Monomethylauristatin F through Monoclonal Antibody Delivery:  Effects of Linker Technology on Efficacy and Toxicity

Svetlana O. Doronina, Brian A. Mendelsohn, Tim D. Bovee, +9

Bioconjugate Chemistry

Mab DegradationImmunologyImmunotherapyMonomethylauristatin FTumor Biology +17

Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

Stephen C. Alley, Dennis R. Benjamin, Scott C. Jeffrey, +4

Bioconjugate Chemistry

ImmunologyImmunotherapyTumor BiologyAmide LinkersMedicinal Chemistry +16

Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate

Nicole M. Okeley, Jamie B. Miyamoto, Xinqun Zhang, +5

Clinical Cancer Research

Lysosomal Trafficking and Cysteine Protease Metabolism Confer Target-specific Cytotoxicity by Peptide-linked Anti-CD30-Auristatin Conjugates

May S.K. Sutherland, Russell J. Sanderson, Kristine A. Gordon, +10

Journal of Biological Chemistry

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA

Clifford D. Mol, A.S. Arvai, Russell J. Sanderson, +5

Cell

Crystal StructureHuman Uracil-dna GlycosylaseProtein InhibitorBiochemistryProtein Assembly +5

<i>In vivo</i>Drug-Linker Stability of an Anti-CD30 Dipeptide-Linked Auristatin Immunoconjugate

Russell J. Sanderson, Michelle A. Hering, Stephanie James, +5

Clinical Cancer Research

Drug TargetingMedicineImmunologyTumor ImmunityImmune Checkpoint Inhibitor +10

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon, +18

Bioconjugate Chemistry

Drug TargetImmunologyMolecular BiologyPharmacotherapyPharmaceutical Chemistry +19

Processivity of Escherichia coli and Rat Liver Mitochondrial Uracil-DNA Glycosylase Is Affected by NaCl Concentration

Samuel Bennett, Russell J. Sanderson, Dale W. Mosbaugh

Biochemistry

GlycobiologyMolecular BiologyEscherichia ColiTotal UracilUracil Removal +17

Measurement of <i>in Vivo</i> Drug Load Distribution of Cysteine-Linked Antibody–Drug Conjugates Using Microscale Liquid Chromatography Mass Spectrometry

Shawna Hengel, Russell J. Sanderson, John Valliere‐Douglass, +3

Analytical Chemistry

Drug TargetEngineeringImmunocytochemical TechniqueBiological Mass SpectrometryDrug-load Distribution +17

Povetacicept, an Enhanced Dual <scp>APRIL</scp>/<scp>BAFF</scp> Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell–Related Autoimmune Diseases

Lawrence S. Evans, Katherine E. Lewis, Daniel Demonte, +22

Arthritis & Rheumatology