Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate

Abstract

MMAE is efficiently released from SGN-35 within CD30(+) cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. This provides mechanistic insight into the pronounced preclinical and clinical antitumor activities observed with SGN-35.