Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates

Stephen C. Alley, Dennis R. Benjamin, Scott C. Jeffrey, +4

Bioconjugate Chemistry

ImmunologyImmunotherapyTumor BiologyAmide LinkersMedicinal Chemistry +16

SGN-CD33A: a novel CD33-targeting antibody–drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML

May S.K. Sutherland, Roland B. Walter, Scott C. Jeffrey, +17

Blood

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

Scott C. Jeffrey, Patrick Burke, Robert P. Lyon, +18

Bioconjugate Chemistry

Drug TargetImmunologyMolecular BiologyPharmacotherapyPharmaceutical Chemistry +19

Development of orally active inhibitors of protein and cellular fucosylation

Nicole M. Okeley, Stephen C. Alley, Martha E. Anderson, +13

Proceedings of the National Academy of Sciences

Vitro FucosylationGlycobiologyImmunologyImmunotherapyTumor Biology +19

Development and Properties of β-Glucuronide Linkers for Monoclonal Antibody−Drug Conjugates

Scott C. Jeffrey, Jamie B. Andreyka, Starr X. Bernhardt, +9

Bioconjugate Chemistry

ImmunologyGlycobiologyMmaf Conjugate C1f6-9bPharmacotherapyImmunotherapy +14

Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody–Drug Conjugates

Patrick Burke, Joseph Z. Hamilton, Scott C. Jeffrey, +11

Molecular Cancer Therapeutics

Metabolic Engineering of Monoclonal Antibody Carbohydrates for Antibody–Drug Conjugation

Nicole M. Okeley, Brian E. Toki, Xinqun Zhang, +4

Bioconjugate Chemistry

Bioorganic ChemistryGlycobiologyPolysaccharideChemical BiologyThiolated Analogue +16

Design, Synthesis, and Biological Evaluation of Antibody−Drug Conjugates Comprised of Potent Camptothecin Analogues

Patrick Burke, Peter D. Senter, David W. Meyer, +7

Bioconjugate Chemistry

Design, Synthesis, and in Vitro Evaluation of Dipeptide-Based Antibody Minor Groove Binder Conjugates

Scott C. Jeffrey, Michael Torgov, Jamie B. Andreyka, +9

Journal of Medicinal Chemistry

The Methylene Alkoxy Carbamate Self‐Immolative Unit: Utilization for the Targeted Delivery of Alcohol‐Containing Payloads with Antibody–Drug Conjugates

Robert V. Kolakowski, Karl T. Haelsig, Kim K. Emmerton, +6

Angewandte Chemie International Edition