Jian‐kang Jiang

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel et al. · Cell Metabolism · 2015 · 1.4K citations · Full text

Life Sciences, Biochemistry, Immunology +16

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

Life Sciences, Biochemistry, Oncology +17

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen et al. · Nature Chemical Biology · 2012 · 825 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +15

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Lesley A. Mathews Griner, Rajarshi Guha, Paul Shinn et al. · Proceedings of the National Academy of Sciences · 2014 · 397 citations · Full text

Medicine, Oncology, Pharmacology +14

Evaluation of Substituted <i>N</i>,<i>N</i>′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

Matthew B. Boxer, Jian‐kang Jiang, Matthew G. Vander Heiden et al. · Journal of Medicinal Chemistry · 2009 · 164 citations

Medicine, Medicinal Chemistry, Pharmacology +15