Jan Balzarini

9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

Jan Balzarini, Lieve Naesens, J. F. A. M. Slachmuylders et al. · AIDS · 1991 · 214 citations

A new class of HIV-1 specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

Hiromichi Tanaka, Masanori Baba, Hiroyuki Hayakawa et al. · Journal of Medicinal Chemistry · 1991 · 138 citations

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA

Carlo Ballatore, Christopher McGuigan, Erik De Clercq et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 65 citations

Novel Amidate Prodrugs, Pharmaceutical Science, Medicine +7

Conversion of 2′,3′‐dideoxyadenosine (ddA) and 2′,3′‐didehydro‐2′,3′‐dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus

Jan Balzarini, J. Kruining, Orson Wedgwood et al. · FEBS Letters · 1997 · 60 citations · Full text

Immunology, Cell Culture, Antiviral Drug +21

Anti-HIV and Anti-HBV Activity and Resistance Profile of 2′,3′-Dideoxy-3′-Thiacytidine (3TC) and Its Arylphosphoramidate Derivative CF 1109

Jan Balzarini, Orson Wedgwood, J. Kruining et al. · Biochemical and Biophysical Research Communications · 1996 · 60 citations · Full text

Medicinal Chemistry, Anti-hbv Activity, Medicine +10