Orson Wedgwood

Conversion of 2′,3′‐dideoxyadenosine (ddA) and 2′,3′‐didehydro‐2′,3′‐dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus

Jan Balzarini, J. Kruining, Orson Wedgwood et al. · FEBS Letters · 1997 · 60 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Anti-HIV and Anti-HBV Activity and Resistance Profile of 2′,3′-Dideoxy-3′-Thiacytidine (3TC) and Its Arylphosphoramidate Derivative CF 1109

Jan Balzarini, Orson Wedgwood, J. Kruining et al. · Biochemical and Biophysical Research Communications · 1996 · 60 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity

Christopher McGuigan, Orson Wedgwood, Erik De Clercq et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 35 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Activities of Masked 2′,3′-Dideoxynucleoside Monophosphate Derivatives against Human Immunodeficiency Virus in Resting Macrophages

Stefano Aquaro, Orson Wedgwood, Christopher J. Yarnold et al. · Antimicrobial Agents and Chemotherapy · 2000 · 21 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture

Adam Siddiqui, Christopher McGuigan, Carlo Ballatore et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 13 citations

Pharmacy, Medicinal Chemistry, Pharmacology +8