Hiroyuki Hayakawa

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

Tadashi Miyasaka, Hiromichi Tanaka, Masanori Baba et al. · Journal of Medicinal Chemistry · 1989 · 382 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Cullin 2 Ubiquitin Ligase Complex, Which Contributes to Degradation of the Retinoblastoma Tumor Suppressor

Kyung-Won Huh, Xiaobo Zhou, Hiroyuki Hayakawa et al. · Journal of Virology · 2007 · 286 citations · Full text

Medicine, Molecular Biology, Oncology +17

A new class of HIV-1 specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

Hiromichi Tanaka, Masanori Baba, Hiroyuki Hayakawa et al. · Journal of Medicinal Chemistry · 1991 · 139 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

2′-Deoxy-4′-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

Atsushi Kawamoto, Eiichi Kodama, Stefan G. Sarafianos et al. · The International Journal of Biochemistry & Cell Biology · 2008 · 125 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Activity against Human Immunodeficiency Virus Type 1, Intracellular Metabolism, and Effects on Human DNA Polymerases of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh et al. · Antimicrobial Agents and Chemotherapy · 2007 · 103 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14