Hirotomo Nakata

Novel <i>bis</i> -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro

Yasuhiro Koh, Hirotomo Nakata, Kenji Maeda et al. · Antimicrobial Agents and Chemotherapy · 2003 · 366 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Spirodiketopiperazine-Based CCR5 Inhibitor Which Preserves CC-Chemokine/CCR5 Interactions and Exerts Potent Activity against R5 Human Immunodeficiency Virus Type 1 In Vitro

Kenji Maeda, Hirotomo Nakata, Yasuhiro Koh et al. · Journal of Virology · 2004 · 221 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Structural and Molecular Interactions of CCR5 Inhibitors with CCR5

Kenji Maeda, Debananda Das, Hiromi Ogata-Aoki et al. · Journal of Biological Chemistry · 2006 · 162 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

2′-Deoxy-4′-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants

Atsushi Kawamoto, Eiichi Kodama, Stefan G. Sarafianos et al. · The International Journal of Biochemistry & Cell Biology · 2008 · 125 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Activity against Human Immunodeficiency Virus Type 1, Intracellular Metabolism, and Effects on Human DNA Polymerases of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Hirotomo Nakata, Masayuki Amano, Yasuhiro Koh et al. · Antimicrobial Agents and Chemotherapy · 2007 · 103 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14