Jos de Man - Concepedia

Author

Jos de Man

Center for Translational Molecular Medicine

Also Known As

Jos De Man, Jos de Man

102

Publications

728

Citations

H-Index

Concepts

All Affiliations

Center for Translational Molecular Medicine Merck & Co., Inc., Rahway, NJ, USA (United States)Radboud University Nijmegen Radboud University Medical Center WuXi AppTec (China)

About

Jos de Man is an author at Center for Translational Molecular Medicine specializing in pharmacology, medicine, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	8	8	359
2	Natural Sciences	6	6	185
3	Biochemistry	2	2	77
4	Health Sciences	1	1	24
5	Cell Biology	1	1	24

Jos de Man

Publications

609

Citations

H-Index

Page 1

	Year	Citations
Comparison of the Cancer Gene Targeting and Biochemical Selectivities of All Targeted Kinase Inhibitors Approved for Clinical Use Joost C.M. Uitdehaag, Jeroen A.D.M. de Roos, Antoon M. van Doornmalen, PLoS ONE Kinase Inhibitor DrugsTumor BiologyClinical UseBiochemical SelectivitiesOncology	2014	99
TTK Inhibitors as a Targeted Therapy for <i>CTNNB1</i> ( <b>β</b> -catenin) Mutant Cancers Guido J.R. Zaman, Jeroen A.D.M. de Roos, Marion A.A. Libouban, Molecular Cancer Therapeutics	2017	63
Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity Joost C.M. Uitdehaag, Jos de Man, Nicole Willemsen‐Seegers, Journal of Molecular Biology Drug TargetSignal TransductionSignaling PathwayMedicineReceptor Tyrosine Kinase	2017	62
Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance Nicole Willemsen‐Seegers, Joost C.M. Uitdehaag, Martine B.W. Prinsen, Journal of Molecular Biology Molecular DockingMedicinal ChemistryDrug TargetMedicineNatural Sciences	2016	49
Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158 Yvonne Grobben, Joost C.M. Uitdehaag, Nicole Willemsen‐Seegers, Journal of Structural Biology X	2019	40
High-Throughput Fluorescence-Based Screening Assays for Tryptophan-Catabolizing Enzymes Nicole Seegers, Antoon M. van Doornmalen, Joost C.M. Uitdehaag, SLAS DISCOVERY Green Fluorescent MoleculeMedicinal ChemistryBiochemistryMedicineNatural Sciences	2014	39
Discovery of 8-Amino-imidazo[1,5-<i>a</i>]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis Jian Liu, Deodial Guiadeen, A. D. Krikorian, ACS Medicinal Chemistry Letters Drug TargetBioorganic ChemistryTyrosine KinaseImmunologyPharmacotherapy	2015	38
Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines Marion A.A. Libouban, Jeroen A.D.M. de Roos, Joost C.M. Uitdehaag, Oncotarget	2017	37
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors Peter C. Ray, Jane Wright, Julia Adam, Bioorganic & Medicinal Chemistry Letters Combinatorial ChemistryMedicinal ChemistryNatural SciencesMedicineOrganic Chemistry	2010	29
Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017 Joost C.M. Uitdehaag, Jeffrey J. Kooijman, Jeroen A.D.M. de Roos, Molecular Cancer Therapeutics	2018	27

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