Martine B.W. Prinsen

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

Ana Maia, J. de Man, Ute Boon et al. · Annals of Oncology · 2015 · 121 citations

Breast Oncology, Medicine, Immune Checkpoint Inhibitor +8

Comparison of the Cancer Gene Targeting and Biochemical Selectivities of All Targeted Kinase Inhibitors Approved for Clinical Use

Joost C.M. Uitdehaag, Jeroen A.D.M. de Roos, Antoon M. van Doornmalen et al. · PLoS ONE · 2014 · 99 citations · Full text

Kinase Inhibitor Drugs, Tumor Biology, Clinical Use +16

Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells

Inge The, Suzan Ruijtenberg, Benjamin Pierre Bouchet et al. · Nature Communications · 2015 · 83 citations · Full text

TTK Inhibitors as a Targeted Therapy for <i>CTNNB1</i> ( <b>β</b> -catenin) Mutant Cancers

Guido J.R. Zaman, Jeroen A.D.M. de Roos, Marion A.A. Libouban et al. · Molecular Cancer Therapeutics · 2017 · 63 citations · Full text

Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity

Joost C.M. Uitdehaag, Jos de Man, Nicole Willemsen‐Seegers et al. · Journal of Molecular Biology · 2017 · 62 citations

Drug Target, Signal Transduction, Signaling Pathway +10