Nicole Willemsen‐Seegers

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

Ana Maia, J. de Man, Ute Boon et al. · Annals of Oncology · 2015 · 123 citations

Medicine, Oncology, Pharmacology +14

Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity

Joost C.M. Uitdehaag, Jos de Man, Nicole Willemsen‐Seegers et al. · Journal of Molecular Biology · 2017 · 63 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance

Nicole Willemsen‐Seegers, Joost C.M. Uitdehaag, Martine B.W. Prinsen et al. · Journal of Molecular Biology · 2016 · 50 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158

Yvonne Grobben, Joost C.M. Uitdehaag, Nicole Willemsen‐Seegers et al. · Journal of Structural Biology X · 2019 · 42 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines

Marion A.A. Libouban, Jeroen A.D.M. de Roos, Joost C.M. Uitdehaag et al. · Oncotarget · 2017 · 37 citations · Full text

Medicine, Cancer Biology, Oncology +16