Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

Yosup Rew, Daqing Sun, Felix González-López de Turiso, +32

Journal of Medicinal Chemistry

Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2

TaeWeon Lee, Ralf Schwandner, Gayathri Swaminath, +11

Molecular Pharmacology

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

Yingcai Wang, Xian‐Yun Jiao, Frank Kayser, +11

Bioorganic & Medicinal Chemistry Letters

Allosteric ModulatorsDrug TargetBiochemistryFirst Synthetic AgonistsMedicine +6

CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity

Victoria A. Assimon, Yangzhong Tang, Jesse D. Vargas, +15

ACS Chemical Biology

Cancer BiologyTumor BiologyMolecular PharmacologyMedicinal ChemistryAnti-cancer Agent +15

Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist

Sean P. Brown, Paul J. Dransfield, Marc Vimolratana, +15

ACS Medicinal Chemistry Letters

Partial Agonist 1Pancreatic IsletsBiochemistryFunctional SelectivityMedicine +10

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

Yingcai Wang, Jiwen Liu, Paul J. Dransfield, +27

ACS Medicinal Chemistry Letters

Combinatorial ChemistryMolecular PhysiologyBiochemistryFunctional SelectivityMedicine +11

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors

Xian‐Yun Jiao, David J. Kopecky, Jinsong Liu, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)MedicineAck1 InhibitorsPharmacology +4

A Facile Route to Vinyl- and Arylphosphonates by Vinyl and Aryl Radical Trapping with (MeO)₃P

Xian‐Yun Jiao, Wesley G. Bentrude

The Journal of Organic Chemistry

Vinylphosphonate Formation via a Novel Cyclization−Vinyl Radical Trapping Sequence

Xian‐Yun Jiao, Wesley G. Bentrude

Journal of the American Chemical Society

Molecular SciencesEngineeringHeterocyclicDonut IconRadical (Chemistry) +8

Radical Clock Reactions under Pseudo-First-Order Conditions Using Catalytic Quantities of Diphenyl Diselenide. A ⁷⁷Se- and ¹¹⁹Sn-NMR Study of the Reaction of Tributylstannane and Diphenyl Diselenide

David Crich, Xian‐Yun Jiao, Qingwei Yao, +1

The Journal of Organic Chemistry

Chemical EngineeringDiphenyl DiselenideRadical KineticsEngineeringCross-coupling Reaction +11