Paul J. Dransfield

A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

Jian Luo, Gayathri Swaminath, Sean P. Brown et al. · PLoS ONE · 2012 · 136 citations · Full text

Glucose Control, Gpr40 Full Agonists, Insulin Signaling +20

Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor

Daniel C.-H. Lin, Qi Guo, Jian Luo et al. · Molecular Pharmacology · 2012 · 119 citations · Full text

Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1

Yumei Xiong, Gayathri Swaminath, Qiong Cao et al. · Molecular and Cellular Endocrinology · 2013 · 88 citations

Molecular Physiology, Signal Transduction, Endocrine Mechanism +10

Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist

Sean P. Brown, Paul J. Dransfield, Marc Vimolratana et al. · ACS Medicinal Chemistry Letters · 2012 · 88 citations · Full text

Partial Agonist 1, Pancreatic Islets, Biochemistry +12

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

Yingcai Wang, Jiwen Liu, Paul J. Dransfield et al. · ACS Medicinal Chemistry Letters · 2013 · 81 citations · Full text

Combinatorial Chemistry, Molecular Physiology, Biochemistry +13