Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Weihai He, Frederick Jia‐Pei Miao, Daniel C.-H. Lin, +6

Nature

Citric Acid CycleSignal TransductionBiochemistryG Protein-coupled ReceptorMedicine +6

GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo

Martin G. Latour, Thierry Alquier, Elizabeth Oseid, +5

Diabetes

Insulin SignalingMetabolic SyndromeFatty AcidsMetabolic SignalingHealth Sciences +14

A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

Jian Luo, Gayathri Swaminath, Sean P. Brown, +15

PLoS ONE

Glucose ControlGpr40 Full AgonistsInsulin SignalingGastrointestinal Peptide HormoneMolecular Pharmacology +18

Escalation of cocaine self‐administration does not depend on altered cocaine‐induced nucleus accumbens dopamine levels

Serge H. Ahmed, Daniel C.-H. Lin, George F. Koob, +1

Journal of Neurochemistry

Substance UseBehavioral AddictionPsychopharmacologyPsychologySocial Sciences +19

A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery

Tracy Tran, Cheng Song, Trang Nguyen, +8

Cell stem cell

UrologyRenal FunctionDisease MechanismMedicineKidney Failure +10

Identification and Pharmacological Characterization of Multiple Allosteric Binding Sites on the Free Fatty Acid 1 Receptor

Daniel C.-H. Lin, Qi Guo, Jian Luo, +12

Molecular Pharmacology

Structural basis for pharmacological modulation of the TRPC6 channel

Yonghong Bai, Xinchao Yu, Hao Chen, +8

eLife

Trpc6 InhibitionCytoskeletonCellular PhysiologyTrpc6 ModulationMolecular Pharmacology +17

Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone

Roberto Ciccocioppo, Daniel C.-H. Lin, Rémi Martin‐Fardon, +1

Psychopharmacology

Substance AbuseBehavioral SciencesSubstance UseBehavioral NeuroscienceAddiction +11

Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat - interactions between the two drugs

Daniel C.-H. Lin, George F. Koob, Athina Markou

Psychopharmacology

NeuropsychologyPsychoactive DrugPsychiatryNeurophysiologyAddiction +11

AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin Secretion and Lowers Glucose Levels in Rodents

Daniel C.-H. Lin, Jane Zhang, Run Zhuang, +16

PLoS ONE