Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

Michele McTigue, John Wickersham, Chris Pinko, +8

Structure

Kinase DomainCrystal StructureAngiogenesisSignal TransductionReceptor Tyrosine Kinase +8

Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

Daniel R. Knighton, Chen‐Chen Kan, Eleanor F. Howland, +4

Nature Structural Biology

BiosynthesisBiochemistryNatural SciencesEnzyme CatalysisMolecular Biology +4

Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1

Ping Chen, Chun Luo, Yali Deng, +9

Cell

Signal Transductionå Crystal StructureCell DivisionSignaling PathwayCell Regulation +6

Structure of the Human Cytomegalovirus Protease Catalytic Domain Reveals a Novel Serine Protease Fold and Catalytic Triad

Ping Chen, Hideaki Tsuge, Robert J. Almassy, +7

Cell

Virus StructureBiochemistryProtein FoldingNatural SciencesMolecular Biology +5

Dimerization of the Human Cytomegalovirus Protease:  Kinetic and Biochemical Characterization of the Catalytic Homodimer

Stephen A. Margosiak, Darin Vanderpool, Wes Sisson, +2

Biochemistry

Protein ChemistryVirus StructureViral ReplicationMolecular VirologyBiochemistry +12

Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in <i>Escherichia coli: </i>Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1)

Ko Suzuki, Chen‐Chen Kan, Wen Chun Hung, +3

Biological Chemistry

Single-chain Recombinant Human Cytomegalovirus Protease

Christopher Pinko, Stephen A. Margosiak, Darin Vanderpool, +3

Journal of Biological Chemistry

Purification of Human Matrilysin Produced inEscherichia coliand Characterization Using a New Optimized Fluorogenic Peptide Substrate

Anthony Welch, Christopher M. Holman, Michelle F. Browner, +3

Archives of Biochemistry and Biophysics

BiosynthesisEngineeringPeptide EngineeringBioanalysisBiotechnology +6

Role of His-224 in the Anomalous pH Dependence of Human Stromelysin-1

Christopher M. Holman, Chen‐Chen Kan, Michael R. Gehring, +1

Biochemistry

Model System for High-Throughput Screening of Novel Human Immunodeficiency Virus Protease Inhibitors in <i>Escherichia coli</i>

Ting-Jen Rachel Cheng, Ashraf Brik, Chi‐Huey Wong, +1

Antimicrobial Agents and Chemotherapy

Pathogen DetectionGlycobiologyAnalytical BiotechnologyProteomicsBiochemistry +15