Eleanor F. Howland

Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

Daniel R. Knighton, Chen‐Chen Kan, Eleanor F. Howland et al. · Nature Structural Biology · 1994 · 197 citations

Biosynthesis, Biochemistry, Natural Sciences +6

AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies

S. E. Webber, Charlotte A. Bartlett, Theodore J. Boritzki et al. · Cancer Chemotherapy and Pharmacology · 1996 · 89 citations

Medicinal Chemistry, Vivo Preclinical Studies, Biochemistry +3

AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

Theodore J. Boritzki, Charlotte A. Barlett, Cathy Zhang et al. · Investigational New Drugs · 1996 · 62 citations

Biochemistry, Glycobiology, Oligonucleotide +2

Structure-Based Design of Substituted Diphenyl Sulfones and Sulfoxides as Lipophilic Inhibitors of Thymidylate Synthase

Terence R. Jones, Stephen E. Webber, Michael D. Varney et al. · Journal of Medicinal Chemistry · 1997 · 43 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Phenyl Phenyl Sulfone +18

Structure-Based Design of Lipophilic Quinazoline Inhibitors of Thymidylate Synthase

Terence R. Jones, Michael D. Varney, Stephen E. Webber et al. · Journal of Medicinal Chemistry · 1996 · 34 citations