Darren Smart

Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives

Hiroyuki Watanabe, John B. Davis, Darren Smart et al. · Journal of Biological Chemistry · 2002 · 592 citations · Full text

Signal Recognition, Cellular Physiology, Molecular Pharmacology +17

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor

Roderick A. Porter, Wai N. Chan, Steven Coulton et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 165 citations · Full text

Functional Selectivity, Medicine, Receptor (Biochemistry) +4

Cannabinoid CB₂ receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain

Steven J. R. Elmes, Maulik D. Jhaveri, Darren Smart et al. · European Journal of Neuroscience · 2004 · 160 citations

‘Entourage’ effects of <i>N</i>‐acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide‐induced vanilloid receptor activation and upon anandamide metabolism

Darren Smart, Kent‐Olov Jonsson, Séverine Vandevoorde et al. · British Journal of Pharmacology · 2002 · 137 citations · Full text

Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

Harshad K. Rami, Mervyn Thompson, Geoffrey Stemp et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 132 citations · Full text

Medicine, Immunology, Antiviral Drug Development +6