Wai N. Chan

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor

Roderick A. Porter, Wai N. Chan, Steven Coulton et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 166 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement

Mark Duxon, Jennifer L. Stretton, Kathryn R. Starr et al. · Psychopharmacology · 2001 · 93 citations

Life Sciences, Neurobiology, Neuroscience +12

Identification of (−)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent

Wai N. Chan, John Evans, Michael S. Hadley et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +5

Profile of SB‐204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures

Neil Upton, T.P. Blackburn, Colin A. Campbell et al. · British Journal of Pharmacology · 1997 · 46 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Characterization of the binding of [³H]‐SB‐204269, a radiolabelled form of the new anticonvulsant SB‐204269, to a novel binding site in rat brain membranes

Hugh J. Herdon, Jeffrey C. Jerman, Tania O. Stean et al. · British Journal of Pharmacology · 1997 · 36 citations · Full text

Medicine, Neuroscience, Pharmacology +13