1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor

Roderick A. Porter, Wai N. Chan, Steven Coulton, +9

Bioorganic & Medicinal Chemistry Letters

Functional SelectivityMedicineReceptor (Biochemistry)Orexin-1 ReceptorNon-peptide Ligand +2

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement

Mark Duxon, Jennifer L. Stretton, Kathryn R. Starr, +10

Psychopharmacology

Behavioral NeuroscienceMedicinePhysiologyReceptor InvolvementOx 1 +6

Identification of (−)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent

Wai N. Chan, John Evans, Michael S. Hadley, +7

Bioorganic & Medicinal Chemistry Letters

Bioorganic ChemistryAntiparasitic AgentMedicinePotential Antimigraine AgentHeterocycle Chemistry +3

Profile of SB‐204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures

Neil Upton, T.P. Blackburn, Colin A. Campbell, +9

British Journal of Pharmacology

Characterization of the binding of [³H]‐SB‐204269, a radiolabelled form of the new anticonvulsant SB‐204269, to a novel binding site in rat brain membranes

Hugh J. Herdon, Jeffrey C. Jerman, Tania O. Stean, +6

British Journal of Pharmacology

Synthesis of Novel <i>trans</i>-4-(Substituted-benzamido)-3,4-dihydro-2<i>H</i>-benzo[<i>b</i>]pyran-3-ol Derivatives as Potential Anticonvulsant Agents with a Distinctive Binding Profile

Wai N. Chan, John Evans, Michael S. Hadley, +7

Journal of Medicinal Chemistry

Bioorganic ChemistryAltmetric Attention ScorePharmacotherapyHeterocycle ChemistryPharmaceutical Chemistry +16

Stereochemical differentiation of anticonvulsant and antihypertensive effects in 4-(fluorobenzoylamino)-benzopyrans

Thomas P. Blackburn, Robin E. Buckingham, Wai N. Chan, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryStereochemical DifferentiationMedicineMechanism Of ActionPharmacotherapy +3

Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity

Wai N. Chan, Michael S. Hadley, John D. Harling, +7

Bioorganic & Medicinal Chemistry Letters

Potential Anticonvulsant ActivityDerivative (Chemistry)MedicineOrganic Chemistry1,2,3,4-Tetrahydroisoquinolinyl- Benzamides +4

Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides

Wai N. Chan, Michael S. Hadley, John D. Harling, +8

Bioorganic & Medicinal Chemistry

Stereochemical preferences and requirement for the 3-hydroxyl group in novel anticonvulsant 4-fluorobenzoylamino benzopyrans

Thomas H. Brown, Colin A. Campbell, Wai N. Chan, +8

Bioorganic & Medicinal Chemistry Letters

3-Hydroxyl GroupBiochemistryMedicineOrganic ChemistryStereoselective Synthesis +5