Orexin A activates locus coeruleus cell firing and increases arousal in the rat

Jim J. Hagan, Ron A. Leslie, Sara Patel, +18

Proceedings of the National Academy of Sciences

Synaptic TransmissionNeurotransmitterAffective NeuroscienceNeurotransmissionSensory Systems +18

The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

D.C Piper, Neil Upton, Martin Smith, +1

European Journal of Neuroscience

GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer’s Disease Brain and Improves Cognitive Performance in Preclinical Models

Andrew D. Medhurst, A.R. Atkins, I.J.M. Beresford, +35

Journal of Pharmacology and Experimental Therapeutics

Characterization of SB‐269970‐A, a selective 5‐HT₇ receptor antagonist

Jim J. Hagan, Gary Price, Nigel Deeks, +10

British Journal of Pharmacology

Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice

Haydn M. Prosser, Catherine H. Gill, Warren D. Hirst, +19

Molecular and Cellular Neuroscience

MedicineGabab1-deficient MiceNeuropharmacologyMolecular NeurobiologyPharmacology +1

SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models

Warren D. Hirst, Tania O. Stean, Derek C. Rogers, +14

European Journal of Pharmacology

Cognitive ScienceNeuropsychologyCognitive NeuroscienceBehavioral NeuroscienceBrain Function +7

BACE1 (β-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

Steve Harrison, Alex Harper, Julie A. Hawkins, +11

Molecular and Cellular Neuroscience

Behavioral ChangesMolecular NeuroscienceBehavioral NeuroscienceNeurotransmitterNeurochemical Deficits +10

Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease

Perdita L. Pugh, Jill Richardson, Simon T. Bate, +2

Behavioural Brain Research

App/ps1 Transgenic ModelCognitive ScienceAlzheimer's DiseaseMedicineDementia +6

Characterization of SB‐271046: A potent, selective and orally active 5‐HT₆ receptor antagonist

Carol Routledge, Steven M. Bromidge, Stephen F. Moss, +10

British Journal of Pharmacology

Receptors Sb-271046PharmacotherapyExperimental PharmacologyActive 5‐HtRat Mest Test +14

The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

Andrew Foley, Keith J. Murphy, Warren D. Hirst, +5

Neuropsychopharmacology

NeuropsychologyCognitive ScienceBrain FunctionBehavioral NeuroscienceCortical Remodeling +7