Roderick A. Porter

A selective orexin-1 receptor antagonist reduces food consumption in male and female rats

Andrea Haynes, Brian A. Jackson, Helen Chapman et al. · Regulatory Peptides · 2000 · 341 citations

Life Sciences, Animal Sciences, Endocrinology +6

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor

Roderick A. Porter, Wai N. Chan, Steven Coulton et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 166 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Structure–activity analysis of truncated orexin-A analogues at the orexin-1 receptor

John G. Darker, Roderick A. Porter, Drake S. Eggleston et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats

Yasuyuki Ishii, John E. Blundell, Jason C. G. Halford et al. · Physiology & Behavior · 2004 · 67 citations

Medicine, Neuroscience, Pharmacology +12

Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders

David Harrison, Andy Billinton, Mark G. Bock et al. · Journal of Medicinal Chemistry · 2023 · 65 citations · Full text

Life Sciences, Neurology, Pharmacology +17