Mervyn Thompson

Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

Harshad K. Rami, Mervyn Thompson, Geoffrey Stemp et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 132 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +5

Characterization of SB-705498, a Potent and Selective Vanilloid Receptor-1 (VR1/TRPV1) Antagonist That Inhibits the Capsaicin-, Acid-, and Heat-Mediated Activation of the Receptor

Martin J. Gunthorpe, Sara Luis Hannan, Darren Smart et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 105 citations

Medicine, Medicinal Chemistry, Pharmacology +17

N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist

Ian T. Forbes, G.A. Kennett, Angela Gadre et al. · Journal of Medicinal Chemistry · 1993 · 67 citations

Medicine, Medicinal Chemistry, Pharmacology +8

5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: A Novel 5-HT2C/5-HT2B Receptor Antagonist with Improved Affinity, Selectivity, and Oral Activity

Ian T. Forbes, P. J. Ham, Deborah H. Booth et al. · Journal of Medicinal Chemistry · 1995 · 61 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 9.Part 8. See Ref. 22. Formal synthesis of (–)-pinidine and total synthesis of (–)-histrionicotoxin, (+)-histrionicotoxin and (–)-histrionicotoxin 235AThis manuscript is dedicated to the sixtieth birthday of Professor L. Tietze.

Edwin C. Davison, Martin E. Fox, Andrew B. Holmes et al. · Journal of the Chemical Society Perkin Transactions 1 · 2002 · 60 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14