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Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

Harshad K. Rami, Mervyn Thompson, Geoffrey Stemp, Steve Fell, Jeffrey C. Jerman, Alexander J. Stevens, Darren Smart, Becky Sargent, Dominic Sanderson, Andrew D. Randall,

Bioorganic & Medicinal Chemistry Letters · 2006 · 132 citations · 7 references

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7

The capsaicin receptor: a heat-activated ion channel in the pain pathway

Michael J. Caterina, Mark Schumacher, Makoto Tominaga et al. · Nature · 1997 · 9.1K citations

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Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

Michael J. Caterina, Andreas Leffler, Annika B. Malmberg et al. · Science · 2000 · 3.5K citations

, , +17

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

John B. Davis, Julie Gray, Martin J. Gunthorpe et al. · Nature · 2000 · 1.8K citations

, , +14

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

Philip D. Hayes, H.J. Meadows, Martin J. Gunthorpe et al. · Pain · 2000 · 310 citations

, , +16

Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist

Martin J. Gunthorpe, Harshad K. Rami, Jeffrey C. Jerman et al. · Neuropharmacology · 2003 · 273 citations

, , +11