Jon T. Seal

Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists

Mahmood Ahmed, Michael A. Briggs, Steven M. Bromidge et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 47 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1

Susan M. Westaway, Mervyn Thompson, Harshad K. Rami et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +4

GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family

Alex Preston, Stephen J. Atkinson, Paul Bamborough et al. · ACS Medicinal Chemistry Letters · 2020 · 32 citations · Full text

Medicine, Oncology, Pharmacology +8

Discovery of <i>N</i>-(3-Fluorophenyl)-1-[(4-([(3<i>S</i>)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate

Susan M. Westaway, Samantha L. Brown, Stephen C. M. Fell et al. · Journal of Medicinal Chemistry · 2009 · 29 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +12

The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor

Susan M. Westaway, Samantha L. Brown, Elizabeth A. Conway et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 13 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14