Andrew S. Cook

Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

Jason Wray, Tüzer Kalkan, Sandra Gómez‐López et al. · Nature Cell Biology · 2011 · 535 citations · Full text

Embryonic Stem Cell, Lineage Plasticity, Induced Pluripotent Stem Cell +10

Identification of (<i>R</i>)-<i>N</i>-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1<i>H</i>-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

Rishi G. Vaswani, Victor Gehling, Les A. Dakin et al. · Journal of Medicinal Chemistry · 2016 · 214 citations · Full text

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Paul V. Fish, P. Filippakopoulos, Gerwyn Bish et al. · Journal of Medicinal Chemistry · 2012 · 195 citations · Full text

Histone Modifications, Pharmaceutical Science, Drug Target +20

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

Constantin Cretu, Anant A. Agrawal, Andrew S. Cook et al. · Molecular Cell · 2018 · 173 citations · Full text

Medicinal Chemistry, Medicine, Natural Sciences +7

EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation

William D. Bradley, Shilpi Arora, Jennifer Busby et al. · Chemistry & Biology · 2014 · 148 citations

Hematological Malignancy, Lymphoid Neoplasia, Medicine +10