Les A. Dakin - Concepedia

Author

Les A. Dakin

AstraZeneca (United States)

Also Known As

Dakin, L.A., L. A. DAKIN, L. Dakin, Les A. Dakin, Les Dakin

Publications

1.9K

Citations

H-Index

Concepts

All Affiliations

AstraZeneca (United States)Boston University Constellation Pharmaceuticals (United States)AstraZeneca (Brazil)Harvard University

About

Les A. Dakin is an author at AstraZeneca (United States) specializing in medicine, drug discovery, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	12	12	872
2	Natural Sciences	8	8	608
3	Biochemistry	8	8	590
4	Engineering	2	2	113
5	Biomolecular Engineering	1	1	34

Les A. Dakin

Publications

1.8K

Citations

H-Index

Page 1

	Year	Citations
Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR) Richard A. Ward, Mark J. Anderton, Susan Ashton, Journal of Medicinal Chemistry Covalent InhibitorsDrug TargetThiol ReactivityTyrosine KinaseMolecular Biology	2013	257
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia Erika Krasnickas Keeton, Kristen McEachern, Keith Dillman, Blood	2013	240
Identification of (<i>R</i>)-<i>N</i>-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1<i>H</i>-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas Rishi G. Vaswani, Victor Gehling, Les A. Dakin, Journal of Medicinal Chemistry	2016	214
EZH2 Inhibitor Efficacy in Non-Hodgkin’s Lymphoma Does Not Require Suppression of H3K27 Monomethylation William D. Bradley, Shilpi Arora, Jennifer Busby, Chemistry & Biology Hematological MalignancyLymphoid NeoplasiaMedicineImmunologyCancer Cell Biology	2014	148
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains Terry D. Crawford, Vickie Tsui, E. Megan Flynn, Journal of Medicinal Chemistry Molecular BiologyChemical BiologyPharmaceutical ChemistryBiological RoleMedicinal Chemistry	2016	117
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases Les A. Dakin, M. Block, Huawei Chen, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryNovel Benzylidene-1,3-thiazolidine-2,4-dionesBiochemistryNatural SciencesMedicine	2012	100
A Mild, Chemoselective Protocol for the Removal of Thioketals and Thioacetals Mediated by Dess−Martin Periodinane Neil F. Langille, Les A. Dakin, James S. Panek Organic Letters	2003	80
Speciation and Mechanistic Studies of Chiral Copper(I) Schiff Base Precursors Mediating Asymmetric Carbenoid Insertion Reactions of Diazoacetates into the Si−H Bond of Silanes Les A. Dakin, Patricia Ong, James S. Panek, Organometallics Materials ScienceInorganic ChemistryChemical EngineeringChiral CopperMechanistic Studies	2000	79
[4 + 2]-Annulations of Chiral Organosilanes: Application to the Total Synthesis of Leucascandrolide A Qibin Su, Les A. Dakin, James S. Panek The Journal of Organic Chemistry	2006	79
Carbenoid insertions into the siliconhydrogen bond catalyzed by chiral copper (I) schiff base complexes Les A. Dakin, Scott E. Schaus, Eric N. Jacobsen, Tetrahedron Letters	1998	74

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