Kristen McEachern

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

Michael Hedvat, Dennis Huszar, Andreas Herrmann et al. · Cancer Cell · 2009 · 529 citations · Full text

Medicine, Oncology, Pharmacology +9

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

Ila Datar, Miguel F. Sanmamed, Jun Wang et al. · Clinical Cancer Research · 2019 · 330 citations · Full text

Medicine, Immunology, Oncology +17

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

Erika Krasnickas Keeton, Kristen McEachern, Keith Dillman et al. · Blood · 2013 · 247 citations

Medicine, Medicinal Chemistry, Pharmacology +11

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Fara Brasó‐Maristany, Simone Filosto, Steven Catchpole et al. · Nature Medicine · 2016 · 245 citations · Full text

Medicine, Cancer Biology, Oncology +17

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

Álvaro de Mingo Pulido, Kay Hänggi, Daiana P. Celias et al. · Immunity · 2021 · 244 citations · Full text

Life Sciences, Immunology, Oncology +12