Gene B. Hubbard

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.3K citations · Full text

Apoptosis, Immunology, Immune Regulation +18

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr et al. · Nature Medicine · 2018 · 2.1K citations · Full text

Lifespan Extension, Allergy, Anti-aging +10

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Remi-Martin Laberge, Yu Sun, Arturo V. Orjalo et al. · Nature Cell Biology · 2015 · 1.1K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +8

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Sarah J. Mitchell, Julio Madrigal‐Matute, Morten Scheibye‐Knudsen et al. · Cell Metabolism · 2016 · 465 citations · Full text

Aging, Longevity, Physiology +7

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

Jeffrey W. Hofmann, Xiaoai Zhao, Marco De Cecco et al. · Cell · 2015 · 301 citations · Full text

Lifespan Extension, Longevity, Physiology +2