5-Fluoro-2-methyl-<i>N</i>-[4-(5<i>H</i>-pyrrolo[2,1-<i>c</i>]- [1,4]benzodiazepin-10(11<i>H</i>)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985):  An Orally Active Arginine Vasopressin Antagonist with Selectivity for V₂Receptors

J. Donald Albright, Marvin F. Reich, Efren G. Delos Santos, +8

Journal of Medicinal Chemistry

Altmetric Attention ScorePharmacotherapyExperimental PharmacologyMolecular PharmacologyMedicinal Chemistry +14

Stereoselective synthesis of β-substituted α,β-unsaturated esters by dialkylcuprate coupling to the enol phosphate of β-keto esters

Fuk‐Wah Sum, Larry Weiler

Canadian Journal of Chemistry

Corresponding Enol Phosphatesβ-Keto EstersEngineeringBiochemistryNatural Sciences +11

Indole Cytosolic Phospholipase A₂α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1<i>H</i>-indol-3-yl]propyl}benzoic Acid, Efipladib

John C. McKew, Katherine L. Lee, Marina W. H. Shen, +27

Journal of Medicinal Chemistry

Inhibition of Cytosolic Phospholipase A₂α: Hit to Lead Optimization

John C. McKew, Megan A. Foley, Paresh Thakker, +13

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryInhibitory ActivityPharmaceutical ScienceBiochemistry +11

Novel (4-Piperidin-1-yl)-phenyl Sulfonamides as Potent and Selective Human β3 Agonists

Baihua Hu, John W. Ellingboe, Stella Han, +11

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +8

2,4-thiazolidinediones as potent and selective human β3 agonists

Baihua Hu, John W. Ellingboe, Iwan Gunawan, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyPharmacologyPharmacological AgentPharmacotherapyDrug Development +2

Structure-Activity Relationship of 6-Methylidene Penems Bearing 6,5 Bicyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors:  Evidence for 1,4-Thiazepine Intermediates with C7 R Stereochemistry by Computational Methods

Aranapakam M. Venkatesan, Atul Agarwal, Takao Abé, +17

Journal of Medicinal Chemistry

Combinatorial ChemistryCrystal StructureBioorganic Chemistry6-Methylidene PenemsOrganic Chemistry +16

Structure–activity study of novel tricyclic benzazepine arginine vasopressin antagonists

Fuk‐Wah Sum, John P. Dusza, Efren Delos Santos, +9

Bioorganic & Medicinal Chemistry Letters

MedicineStructure–activity StudyMechanism Of ActionPharmacological AgentPharmacotherapy +3

(4-Piperidin-1-yl)phenyl Amides:  Potent and Selective Human β₃ Agonists

Baihua Hu, John W. Ellingboe, Stella Han, +5

Journal of Medicinal Chemistry

Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists

Fuk‐Wah Sum, Victoria Wong, Stella Han, +3

Bioorganic & Medicinal Chemistry Letters

Cyclic Amine SulfonamidesMolecular PharmacologyBiochemistryMedicineMechanism Of Action +5