A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Alessia Balestrini, Victory Joseph, Michelle Dourado, +57

The Journal of Experimental Medicine

InflammationAsthmaTrpa1 InhibitorAnti-inflammatoryInflammatory Lung Disease +13

Carbenoid versus Vinylogous Reactivity in Rhodium(II)-Stabilized Vinylcarbenoids

Huw M. L. Davies, Baihua Hu, Elie Saikali, +1

The Journal of Organic Chemistry

Baihua HuInorganic ChemistryChemical MeasurementEngineeringChemical Analysis +9

Novel synthesis of a conformationally-constrained analog of DDATHF

Edward C. Taylor, Ping Zhou, Lee D. Jennings, +3

Tetrahedron Letters

EngineeringSelf-assemblyConformational StudyChemistrySynthesis Method +2

Indole Cytosolic Phospholipase A₂α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1<i>H</i>-indol-3-yl]propyl}benzoic Acid, Efipladib

John C. McKew, Katherine L. Lee, Marina W. H. Shen, +27

Journal of Medicinal Chemistry

Synthesis and Structure−Activity Relationship of α-Sulfonylhydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Venkatesan Aranapakam, G Grosu, Jamie M. Davis, +12

Journal of Medicinal Chemistry

Pharmaceutical ScienceChemical BiologyPharmaceutical ChemistryInflammationMedicinal Chemistry +16

Highly stereoselective [3 + 2] annulations by cyclopropanation of vinyl ethers with rhodium(II)-stabilized vinylcarbenoids followed by a formally forbidden 1,3-sigmatropic rearrangement

Huw M. L. Davies, Baihua Hu

The Journal of Organic Chemistry

Chemical EngineeringMolecular SciencesEngineeringHeterocyclicAlkene Metathesis +9

Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRβ

Baihua Hu, Raymound Unwalla, Michael D. Collini, +6

Bioorganic & Medicinal Chemistry

Molecular PharmacologyDrug TargetFunctional SelectivityMedicineImmunology +5

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Nicole Blaquière, Georgette M. Castanedo, Jason D. Burch, +32

Journal of Medicinal Chemistry

Lead CompoundsDrug TargetLead IdentificationChemical BiologyPharmaceutical Chemistry +22

Discovery of Phenyl Acetic Acid Substituted Quinolines as Novel Liver X Receptor Agonists for the Treatment of Atherosclerosis

Baihua Hu, Michael D. Collini, Rayomand J. Unwalla, +21

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryPharmaceutical ScienceQuinolines 15Biochemistry +12

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Jack A. Terrett, Huifen Chen, Daniel G. Shore, +36

Journal of Medicinal Chemistry