Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

Yuya Oguro, Naoki Miyamoto, Kengo Okada, +7

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryNatural SciencesMedicine +7

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

Yoshinori Ishikawa, Kanae Gamo, Masato Yabuki, +18

Molecular Cancer Therapeutics

Demethylase 1AMixed-phenotype Acute LeukemiaMyeloid NeoplasiaHematological MalignancySignaling Pathway +15

Discovery of a Piperidine-4-carboxamide CCR5 Antagonist (TAK-220) with Highly Potent Anti-HIV-1 Activity

Shinichi Imamura, Takashi Ichikawa, Youichi Nishikawa, +6

Journal of Medicinal Chemistry

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama, +12

Bioorganic & Medicinal Chemistry

Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors

Shigemitsu Matsumoto, Naoki Miyamoto, Takaharu Hirayama, +9

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryVegfr2 Kinase InhibitorsMedicinal ChemistryMedicineNatural Sciences +9

Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA

Katherine A. Rawls, P. Therese Lang, Jun Takeuchi, +5

Bioorganic & Medicinal Chemistry Letters

Pulmonary TuberculosisDrug TargetBiochemistryNatural SciencesRational Drug Design +8

Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics

Yuya Oguro, Douglas R. Cary, Naoki Miyamoto, +5

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineDrug DiscoveryRational Drug DesignPharmacotherapy +6

CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives

Shinichi Imamura, Youichi Nishikawa, Takashi Ichikawa, +7

Bioorganic & Medicinal Chemistry

Piperidine-4-carboxamide DerivativesMedicineImmunologyAntiviral Drug DevelopmentAntiviral Therapy +8

Kainic acid-induced dorsal and ventral hippocampal seizures in rats

Koichi Akaike, Shigeya Tanaka, Hideshi Tojo, +3

Brain Research

NeurophysiologyNeuropharmacologyNeurotransmissionNeurologyNeuroscience +5

Are Nonfunctioning Pituitary Adenomas Extending into the Cavernous Sinus Aggressive and/or Invasive?

Shunichi Yokoyama, Hirofumi Hirano, Koichi Moroki, +3

Neurosurgery

Neuro-oncologyPituitary GlandSurgical PathologyPathologyCavernous Sinus +8