Shinichi Imamura

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: Novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

Yuya Oguro, Naoki Miyamoto, Kengo Okada et al. · Bioorganic & Medicinal Chemistry · 2010 · 117 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +9

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

Yoshinori Ishikawa, Kanae Gamo, Masato Yabuki et al. · Molecular Cancer Therapeutics · 2016 · 103 citations

Demethylase 1A, Mixed-phenotype Acute Leukemia, Myeloid Neoplasia +17

Discovery of a Piperidine-4-carboxamide CCR5 Antagonist (TAK-220) with Highly Potent Anti-HIV-1 Activity

Shinichi Imamura, Takashi Ichikawa, Youichi Nishikawa et al. · Journal of Medicinal Chemistry · 2006 · 71 citations · Full text

Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

Naoki Miyamoto, Nozomu Sakai, Takaharu Hirayama et al. · Bioorganic & Medicinal Chemistry · 2013 · 70 citations · Full text

Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors

Shigemitsu Matsumoto, Naoki Miyamoto, Takaharu Hirayama et al. · Bioorganic & Medicinal Chemistry · 2013 · 54 citations · Full text

Combinatorial Chemistry, Vegfr2 Kinase Inhibitors, Medicinal Chemistry +11