J A Ledbetter

CTLA-4 is a second receptor for the B cell activation antigen B7.

Peter S. Linsley, William Brady, M Urnes et al. · The Journal of Experimental Medicine · 1991 · 1.7K citations · Full text

Functional Properties, Functional Interactions, Adaptive Immune System +14

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

Lieping Chen, Stephanie Ashe, William Brady et al. · Cell · 1992 · 1.1K citations

Immunological Memory, Cancer Immunosurveillance, Autoimmune Disease +10

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

P S Linsley, JoAnne L. Greene, William Brady et al. · Immunity · 1994 · 961 citations

Human B7-1, Signal Transduction, Autoimmune Disease +13

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

Alejandro Aruffo, Mary Farrington, Diane Hollenbaugh et al. · Cell · 1993 · 824 citations

Activated T Cells, Allergy, Autoimmune Disease +8

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

Peter S. Linsley, Edward A. Clark, J A Ledbetter · Proceedings of the National Academy of Sciences · 1990 · 748 citations · Full text

Adaptive Immune System, Immunology, Immune Regulation +20