CTLA-4 is a second receptor for the B cell activation antigen B7.

Peter S. Linsley, William Brady, M Urnes, +3

The Journal of Experimental Medicine

Functional PropertiesFunctional InteractionsAdaptive Immune SystemImmunologyImmune Regulation +12

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

Lieping Chen, Stephanie Ashe, William Brady, +5

Cell

Immunological MemoryCancer ImmunosurveillanceAutoimmune DiseaseB7 CounterreceptorImmunology +8

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

P S Linsley, JoAnne L. Greene, William Brady, +3

Immunity

Human B7-1Signal TransductionAutoimmune DiseaseCtla-4 ReceptorsImmunology +11

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

Alejandro Aruffo, Mary Farrington, Diane Hollenbaugh, +12

Cell

Activated T CellsAllergyAutoimmune DiseaseT-regulatory CellImmunology +6

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

Peter S. Linsley, Edward A. Clark, J A Ledbetter

Proceedings of the National Academy of Sciences

Adaptive Immune SystemImmunologyImmune RegulationPathologyImmunologic Mechanism +18

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

Patrick Tan, Claudio Anasetti, John A. Hansen, +5

The Journal of Experimental Medicine

T Cell HyporesponsivenessAdaptive Immune SystemT-regulatory CellImmunologyAlloantigen-specific Hyporesponsiveness +15

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

J A Ledbetter, C H June, Laura S. Grosmaire, +1

Proceedings of the National Academy of Sciences

T-regulatory CellImmunologyImmune RegulationImmunodominanceImmunologic Mechanism +17

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.

J A Ledbetter, Nicholas K. Tonks, Edmond H. Fischer, +1

Proceedings of the National Academy of Sciences

Immune RegulationImmunologyImmunodominanceImmunologic MechanismCd45 Mab +14

Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

Horacio M. Serra, John F. Krowka, J A Ledbetter, +1

The Journal of Immunology

Autoimmune DiseaseLymphocyte DevelopmentAdaptive Immune SystemCdw29 ExpressionMaturation Stages +12

Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation

Peter A. Kiener, Patricia M. Davis, Bruce Rankin, +4

The Journal of Immunology