Makoto Kitade

TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka et al. · Molecular Cancer Therapeutics · 2014 · 140 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1<i>H</i>-pyrazol-4-yl)-1<i>H</i>-imidazol-1-yl)-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor

Takao Uno, Yuichi Kawai, Satoshi Yamashita et al. · Journal of Medicinal Chemistry · 2018 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Structure and synthesis of petrosynes, new acetylenic enol ether glycerides from the Okinawan marine sponge of the genus Petrosia

Kazuo Iguchi, Makoto Kitade, Toshihiko Kashiwagi et al. · The Journal of Organic Chemistry · 1993 · 37 citations

Natural Sciences, Chemistry, Marine Sciences +14

A novel cinnamic acid derivative that inhibits Cdc25 dual‐specificity phosphatase activity

Yoshimi Aoyagi, Norio Masuko, Shuichi Ohkubo et al. · Cancer Science · 2005 · 24 citations · Full text

Medicine, Oncology, Pharmacology +14

Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors

Chihoko Yoshimura, Satoru Nagatoishi, Daisuke Kuroda et al. · Journal of Medicinal Chemistry · 2021 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13