TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka, +10

Molecular Cancer Therapeutics

Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1<i>H</i>-pyrazol-4-yl)-1<i>H</i>-imidazol-1-yl)-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor

Takao Uno, Yuichi Kawai, Satoshi Yamashita, +13

Journal of Medicinal Chemistry

Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting

Susumu Nakade, Tomoya Ohno, Junsaku Kitagawa, +5

Cancer Chemotherapy and Pharmacology

Drug SafetyChemotherapy-induced NauseaPharmacologyClinical PharmacologyPharmacotherapy +4

Discovery of Futibatinib: The First Covalent FGFR Kinase Inhibitor in Clinical Use

Satoru Ito, Sachie Otsuki, Hirokazu Ohsawa, +15

ACS Medicinal Chemistry Letters

Binding Parameters of Valproic Acid to Serum Protein in Healthy Adults at Steady State

Yasuo Kodama, Yuichi Koike, Hiroo Kimoto, +4

Therapeutic Drug Monitoring

Antagonism of Saikosaponin-Induced Prostaglandin E2 Release by Baicalein in C6 Rat Glioma Cells.

Reiki Kyo, Norimichi Nakahata, Yasuo Kodama, +3

Biological and Pharmaceutical Bulletin

Chemoprevention StrategyPge2 ReleaseBupleuri RadixGliomaSaikosaponin B1 +14

The quality of conduct in Japanese clinical trials

Shunsuke Ono, Yasuo Kodama, Taku Nagao, +1

Controlled Clinical Trials

Clinical EffectivenessPatient SafetyClinical TrialsRandomized Controlled TrialResearch Ethics +4

Gender- or age-related binding characteristics of valproic acid to serum proteins in adult patients with epilepsy

Yasuo Kodama, Hirofumi Kodama, Masae Kuranari, +4

European Journal of Pharmaceutics and Biopharmaceutics

Valproic AcidMedicineAdult PatientsNeuropharmacologyNeurochemical Biomarkers +5

Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors

Chihoko Yoshimura, Satoru Nagatoishi, Daisuke Kuroda, +10

Journal of Medicinal Chemistry

Cytosolic Hsp90Cytosolic Hsp90 InhibitorsAnalytical UltracentrifugationChemical BiologyMolecular Pharmacology +15

No Effect of Gender or Age on Binding Characteristics of Valproic Acid to Serum Proteins in Pediatric Patients with Epilepsy

Yasuo Kodama, Hirofumi Kodama, Masae Kuranari, +3

The Journal of Clinical Pharmacology

Valproic AcidMedicinePediatric PatientsNeurologyPediatric Population +4