Shuichi Ohkubo

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Sawako Suzuki, Tomoaki Tanaka, Masha V. Poyurovsky et al. · Proceedings of the National Academy of Sciences · 2010 · 685 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes

Tomoaki Tanaka, Shuichi Ohkubo, Ichiro Tatsuno et al. · Cell · 2007 · 174 citations · Full text

Life Sciences, Genetics, Molecular Biology +11

TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka et al. · Molecular Cancer Therapeutics · 2014 · 140 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

Hiroyuki Hosokawa, Tomoaki Tanaka, Yutaka Suzuki et al. · Proceedings of the National Academy of Sciences · 2013 · 101 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors

Akihiko Shimomura, Noboru Yamamoto, Shunsuke Kondo et al. · Molecular Cancer Therapeutics · 2019 · 90 citations

Medicine, Pharmacokinetics, Pharmacology +8