DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao, Xiaoguang Liu, Yilei Zhang, +10

Nature

Reductive StressBiochemistryDhodh-mediated Ferroptosis DefencePathologyReactive Oxygen Specie +4

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

Xiaoguang Liu, Litong Nie, Yilei Zhang, +16

Nature Cell Biology

Actin Cytoskeleton VulnerabilityProtein SecretionNatural SciencesMolecular BiologyCell Death +7

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Sawako Suzuki, Tomoaki Tanaka, Masha V. Poyurovsky, +13

Proceedings of the National Academy of Sciences

Lipid PeroxidationCell DeathMolecular BiologyPhosphate-activated GlutaminaseReactive Oxygen Species +15

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu, Kellen Olszewski, Yilei Zhang, +14

Nature Cell Biology

Disulfide StressTargetable Metabolic VulnerabilityCystine Transporter RegulationBiochemistryMedicine +10

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

Pranavi Koppula, Guang Lei, Yilei Zhang, +11

Nature Communications

SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells

Yuelong Yan, Hongqi Teng, Qinglei Hang, +12

Nature Communications

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Alexandra Zanin‐Zhorov, Jonathan M. Weiss, Melanie Nyuydzefe, +18

Proceedings of the National Academy of Sciences

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismStat3-dependent Mechanism +22

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2

Marshall Urist, Tomoaki Tanaka, Masha V. Poyurovsky, +1

Genes & Development

ChromatinGenome InstabilityCancer ResearchDna DamageDna-damage Checkpoint +13

The Mdm2 RING domain C‐terminus is required for supramolecular assembly and ubiquitin ligase activity

Masha V. Poyurovsky, Christina Priest, Alex Kentsis, +4

The EMBO Journal

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

Yan Zhu, Masha V. Poyurovsky, Yingchun Li, +4

Molecular Cell

Protein BiosynthesisMolecular BiologyRibosomal Protein S7MedicineCell Biology +1