Guang Lei

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao, Xiaoguang Liu, Yilei Zhang et al. · Nature · 2021 · 1.6K citations · Full text

Reductive Stress, Biochemistry, Dhodh-mediated Ferroptosis Defence +6

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Guang Lei, Yilei Zhang, Pranavi Koppula et al. · Cell Research · 2020 · 1.3K citations · Full text

Tumor Suppression, Apoptosis, Radiation Exposure +11

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

Xiaoguang Liu, Litong Nie, Yilei Zhang et al. · Nature Cell Biology · 2023 · 1K citations · Full text

Actin Cytoskeleton Vulnerability, Protein Secretion, Natural Sciences +9

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Yilei Zhang, Robert V. Swanda, Litong Nie et al. · Nature Communications · 2021 · 669 citations · Full text

Glutathione Peroxidase 4, Lipid Peroxidation, Molecular Biology +20

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu, Kellen Olszewski, Yilei Zhang et al. · Nature Cell Biology · 2020 · 558 citations · Full text

Disulfide Stress, Targetable Metabolic Vulnerability, Cystine Transporter Regulation +12