Chihoko Yoshimura

TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models

Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka et al. · Molecular Cancer Therapeutics · 2014 · 140 citations

Medicine, Medicinal Chemistry, Pharmacology +11

TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer Models

Chihoko Yoshimura, Hiromi Muraoka, Hiroaki Ochiiwa et al. · Molecular Cancer Therapeutics · 2019 · 67 citations

Medicine, Oncology, Pharmacology +13

Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1<i>H</i>-pyrazol-4-yl)-1<i>H</i>-imidazol-1-yl)-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor

Takao Uno, Yuichi Kawai, Satoshi Yamashita et al. · Journal of Medicinal Chemistry · 2018 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia

Hiroaki Ochiiwa, Guzhanuer Ailiken, Masataka Yokoyama et al. · Oncogene · 2021 · 32 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways

Hiromi Muraoka, Chihoko Yoshimura, Rumi Kawabata et al. · Cancer Science · 2019 · 24 citations · Full text

Medicine, Oncology, Pharmacology +15