Sichen Chang

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents

Julie L. Engers, Alice L. Rodriguez, Leah C. Konkol et al. · Journal of Medicinal Chemistry · 2015 · 68 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

A Novel M ₁ PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Jerri M. Rook, Jeanette L. Bertron, Hyekyung P. Cho et al. · ACS Chemical Neuroscience · 2018 · 64 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Diverse Effects on M₁ Signaling and Adverse Effect Liability within a Series of M₁ Ago-PAMs

Jerri M. Rook, Masahito Abe, Hyekyung P. Cho et al. · ACS Chemical Neuroscience · 2016 · 57 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery of VU0467485/AZ13713945: An M₄ PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

Michael R. Wood, Meredith J. Noetzel, Bruce J. Melancon et al. · ACS Medicinal Chemistry Letters · 2016 · 54 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Design and Synthesis of <i>N</i>-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu₃ NAMs

Julie L. Engers, Katrina A. Bollinger, Rebecca L. Weiner et al. · ACS Medicinal Chemistry Letters · 2017 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14