Jeanette L. Bertron

A Novel M ₁ PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Jerri M. Rook, Jeanette L. Bertron, Hyekyung P. Cho et al. · ACS Chemical Neuroscience · 2018 · 64 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides

James C. Tarr, Michael R. Wood, Meredith J. Noetzel et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels

Hao Shao, Xiaokai Li, Shigenari Hayashi et al. · Bioorganic & Medicinal Chemistry Letters · 2021 · 19 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core

Jeanette L. Bertron, Hyekyung P. Cho, Pedro M. García-Barrantes et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 14 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +8