C.J. Springer

The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino] benzoic acid

Andrew Sunters, C.J. Springer, Kenneth D. Bagshawe et al. · Biochemical Pharmacology · 1992 · 96 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +11

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts.

D C Blakey, P. J. Burke, D. Huw Davies et al. · PubMed · 1996 · 60 citations

Pharmacy, Oncology, Pharmacology +16

Gene-directed enzyme prodrug therapy (GDEPT): choice of prodrugs

C.J. Springer, Ion Niculescu‐Duvaz · Advanced Drug Delivery Reviews · 1996 · 50 citations

Pharmacy, Pharmaceutical Biotechnology, Pharmacology +7

ChemInform Abstract: Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody‐Directed Enzyme Prodrug Therapy (ADEPT).

C.J. Springer, Robert I. Dowell, P. J. Burke et al. · ChemInform · 1996 · 15 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9