Robert I. Dowell

Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy

Caroline J. Springer, Robert I. Dowell, P. J. Burke et al. · Journal of Medicinal Chemistry · 1995 · 90 citations

Combinatorial Chemistry, Pharmaceutical Science, Bioorganic Chemistry +18

Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors

G. C. CRAWLEY, Robert I. Dowell, Philip N. Edwards et al. · Journal of Medicinal Chemistry · 1992 · 84 citations · Full text

Pharmaceutical Science, Pharmacotherapy, New Series +16

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts.

D C Blakey, P. J. Burke, D. Huw Davies et al. · PubMed · 1996 · 60 citations

Colorectal Tumor Xenografts, Immunology, Pathology +16

New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy:  Alternatives to the Amide Link

Robert I. Dowell, Caroline J. Springer, D. Huw Davies et al. · Journal of Medicinal Chemistry · 1996 · 42 citations

Novel inhibitors of prolyl 4-hydroxylase

Robert I. Dowell, Elizabeth M. Hadley · Journal of Medicinal Chemistry · 1992 · 39 citations · Full text

Aldo-keto Reductase, 5-Acyl Sulfonamides, Chemical Biology +16