Yuan-Fang Wang

Novel <i>bis</i> -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro

Yasuhiro Koh, Hirotomo Nakata, Kenji Maeda et al. · Antimicrobial Agents and Chemotherapy · 2003 · 366 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Kinetic, Stability, and Structural Changes in High-resolution Crystal Structures of HIV-1 Protease with Drug-resistant Mutations L24I, I50V, and G73S

Fengling Liu, Péter Boross, Yuan-Fang Wang et al. · Journal of Molecular Biology · 2005 · 84 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla et al. · Journal of Medicinal Chemistry · 2017 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro

Masayuki Amano, Yasuhiro Koh, Debananda Das et al. · Antimicrobial Agents and Chemotherapy · 2007 · 68 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies

Arun K. Ghosh, Sofiya Leshchenko-Yashchuk, David D. Anderson et al. · Journal of Medicinal Chemistry · 2009 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17