An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

Mathias Chamaillard, Masahito Hashimoto, Yasuo Horie, +12

Nature Immunology

Essential RoleBiochemistryBacteriologyMicrobiologyMolecular Microbiology +2

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

Sanjeev Shangary, Dongguang Qin, Donna McEachern, +18

Proceedings of the National Academy of Sciences

Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors

Ke Ding, Yipin Lu, Zaneta Nikolovska‐Coleska, +10

Journal of the American Chemical Society

Molecular DockingMedicinal ChemistryDrug TargetDrug DesignNatural P53 Peptide +13

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

Tsuyoshi Tanabe, Mathias Chamaillard, Yasunori Ogura, +10

The EMBO Journal

Molecular CharacterizationMuramyl Dipeptide RecognitionBiochemistryNatural SciencesBiomolecular Analysis +6

Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins

Guoping Wang, Zaneta Nikolovska‐Coleska, Chao‐Yie Yang, +15

Journal of Medicinal Chemistry

A Potent and Orally Active Antagonist (SM-406/AT-406) of Multiple Inhibitor of Apoptosis Proteins (IAPs) in Clinical Development for Cancer Treatment

Qian Cai, Haiying Sun, Yuefeng Peng, +14

Journal of Medicinal Chemistry

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo

Junya Masumoto, Kangkang Yang, Sooryanarayana Varambally, +12

The Journal of Experimental Medicine

Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP

Haiying Sun, Zaneta Nikolovska‐Coleska, Jianfeng Lü, +10

Journal of the American Chemical Society

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

Jianfeng Lü, Longchuan Bai, Haiying Sun, +10

Cancer Research

Tumor RegressionApoptosis ProteinApoptosisImmunologyCell Death +16

Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

Shanghai Yu, Dongguang Qin, Sanjeev Shangary, +9

Journal of Medicinal Chemistry