Michael Edlund

<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Oliver Lenz, Thierry Verbinnen, Tse‐I Lin et al. · Antimicrobial Agents and Chemotherapy · 2010 · 210 citations · Full text

Molecular Virology, Viral Hepatitis, Pathogenesis +14

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Tse‐I Lin, Oliver Lenz, Gregory Fanning et al. · Antimicrobial Agents and Chemotherapy · 2009 · 190 citations · Full text

Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis

Assar Bäckman, Annelii Ny, Michael Edlund et al. · Journal of Investigative Dermatology · 2002 · 174 citations · Full text

Allergy, Epidermal Overexpression, Chronic Itchy Dermatitis +7

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Pierre Raboisson, Herman de Kock, Åsa Rosenquist et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 136 citations

Novel Series, Biochemistry, Structure–activity Relationship Study +7

Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

Maxwell D. Cummings, Jimmy Lindberg, Tse‐I Lin et al. · Angewandte Chemie International Edition · 2010 · 94 citations