<i>In Vitro</i> Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Oliver Lenz, Thierry Verbinnen, Tse‐I Lin, +16

Antimicrobial Agents and Chemotherapy

Molecular VirologyViral HepatitisPathogenesisImmunologyHcv Genotype 1 +12

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Tse‐I Lin, Oliver Lenz, Gregory Fanning, +12

Antimicrobial Agents and Chemotherapy

Epidermal Overexpression of Stratum Corneum Chymotryptic Enzyme in Mice: A Model for Chronic Itchy Dermatitis

Assar Bäckman, Annelii Ny, Michael Edlund, +7

Journal of Investigative Dermatology

AllergyEpidermal OverexpressionChronic Itchy DermatitisAtopic DermatitisContact Dermatitis +5

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

Pierre Raboisson, Herman de Kock, Åsa Rosenquist, +22

Bioorganic & Medicinal Chemistry Letters

Novel SeriesBiochemistryStructure–activity Relationship StudyMedicineAntiviral Drug Development +5

Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

Maxwell D. Cummings, Jimmy Lindberg, Tse‐I Lin, +13

Angewandte Chemie International Edition

BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells

Anne Jämsä, Oscar Belda, Michael Edlund, +1

Journal of Biomedical Science

Recombinant Human-Milk Bile-Salt-Stimulated Lipase. Functional Properties are Retained in the Absence of Glycosylation and the Unique Proline-Rich Repeats

Lars Bläckberg, Mats Strömqvist, Michael Edlund, +4

European Journal of Biochemistry

Bile-salt ActivationBiosynthesisFunctional PropertiesBiochemistryNatural Sciences +11

Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents

Magnus Nilsson, Anna Karin Belfrage, Stefan B. Lindström, +21

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineAntiviral Drug DevelopmentAntiviral TherapyPotent Inhibitors +5

Recombinant human bile salt-stimulated lipase: an example of defectiveO-glycosylation of a protein produced in milk of transgenic mice

Mats Strömqvist, Jan Törnell, Michael Edlund, +5

Transgenic Research

Salt-stimulated LipaseLipid SynthesisBiochemistryBiliary TractNatural Sciences +8

Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors

Sandrine Vendeville, Magnus Nilsson, Herman de Kock, +25

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesAntiviral Drug Development +7