Efficiency of signalling through cytokine receptors depends critically on receptor orientation

Rashid Syed, Scott W. Reid, Cuiwei Li, +15

Nature

InflammationCytokineMolecular PhysiologySignal TransductionFunctional Selectivity +11

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M.A. McDonough, Vivian Li, Emily Flashman, +14

Proceedings of the National Academy of Sciences

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Annette Bak, Anu Gore, Evelyn Yanez, +11

Journal of Pharmaceutical Sciences

Co‐crystal ApproachPharmaceutical ScienceChemical MeasurementWater‐insoluble CompoundMedicine +5

NMR structure of human erythropoietin and a comparison with its receptor bound conformation

Janet C. Cheetham, D.M. Smith, Kenneth H. Aoki, +5

Nature Structural Biology

BiochemistryNmr StructureNatural SciencesMolecular BiologyHeme Signaling +3

The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF·5G9 complex 1 1Edited by D. C. Rees

Mingdong Huang, Rashid Syed, E.A. Stura, +5

Journal of Molecular Biology

BiochemistryImmunologyHematologyImmune RegulationHemostasis +7

Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design

Robert A. Grant, C.N. Hiremath, David J. Filman, +3

Current Biology

Virus StructureDrug DesignMedicineAntiviral Drug DevelopmentPoliovirus Complexes +6

Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (<i>S</i>)-2-((1<i>S</i>,2<i>S</i>,4<i>R</i>)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5<i>H</i>)-one (AMG 221)

Murielle M. Véniant, Clarence Hale, Randall W. Hungate, +23

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryMethyl GroupBiochemistryC-5 Position +12

The Majority of Stem Cell Factor Exists as Monomer under Physiological Conditions

Yueh‐Rong Hsu, Gay‐May Wu, Elizabeth A. Mendiaz, +8

Journal of Biological Chemistry

Discovery of Highly Selective and Potent p38 Inhibitors Based on a Phthalazine Scaffold

Brad Herberich, Guoqiang Cao, Partha Chakrabarti, +21

Journal of Medicinal Chemistry

A highly enantioselective catalyst for asymmetric hydroformylation of [2.2.1]-bicyclic olefins

Jinkun Huang, Emilio E. Bunel, Alan M. Allgeier, +12

Tetrahedron Letters

Chemical EngineeringEngineeringAlkene MetathesisAsymmetric HydroformylationOrganic Chemistry +4